Bioactive Small Molecules
Medchemexpress LLC TMX-2039 | 2488892-01-7 | C17H20BrFN6O3S | 50 MG
TMX-2039 is a pan-CDK inhibitor targeting both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcriptional CDKs (CDK7 and CDK9). It exhibits high potency with low nanomolar IC50 values against several CDKs and can also function as a ligand for target proteins in PROTAC applications.
- Broad-spectrum CDK inhibition: Inhibits multiple cyclin-dependent kinases involved in cell cycle progression and gene transcription.
- High potency: Demonstrates low nanomolar IC50s against several CDKs, particularly CDK2 and CDK5.
- PROTAC ligand: Can be used as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras) applications.
- High purity: Reported purity of 99.42%.
- Research use only: Suitable for research applications.
Medchemexpress LLC Dmtr-tna-g(o6-conph2)(n2ac)-amidite | 325683-97-4 | C54H57N8O9P | 1 MG
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a purine nucleoside analog. These analogs demonstrate broad antitumor activity, specifically targeting indolent lymphoid malignancies. Their mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis.
- Purine nucleoside analog
- Exhibits broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 25mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Chimmitecan | 100MG
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin) a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560) is a potent inhibitor of topoisomerase I Chimmitecan exhibits anticancer activity[1]
Medchemexpress LLC FGF basic/bFGF Huma 2ug
FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (K128N solution) consists of 155 amino acids produced by E coli with tag free
Medchemexpress LLC KDM2B-IN-4 | 1966933-85-6 | >99.6% | 376.49 | 50 MG
KDM2B-IN-4 is a potent histone demethylase KDM2B inhibitor with an IC50 of 1.12 nM. This compound is suitable for research into hyperproliferative diseases, including various types of cancers.
- Potent histone demethylase KDM2B inhibitor
- IC50 of 1.12 nM
- Useful for hyperproliferative disease research
- Applicable in cancer research
Eurofins Discoverx Bromosporine, 10 mg. (92-1239)
Bromosporine is a synthetic small molecule pan-bromodomain inhibitor developed by the Structural Genomics Consortium for research. It is shown to accelerate FRAP recovery of BRD4 and CREBBP in cells at 1uM concentration. Bromodomains are implicated in multiple cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction. Provided as 10 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
eMolecules 1144035-53-9 | Medchem Express | PF-8380 | 5mg | 446262820 | HY-13344 | MFCD20527274 | 478.33 | C22H21Cl2N3O5
Ambeed | 6-Benzyl-24-dichloro-5H-pyrrolo[34-d]pyrimidin-7(6H)-one | 100mg | 600846205 | A711470 | 1207368-82-8 | MFCD23704678 | 294.140 | C13H9Cl2N3O
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Selleck Chemical LLC Afatinib S1011-200MG
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0 5 0 4 10 14 1 nM for EGFRwt EGFR L858R EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4) respectively Afatinib induces autophagy
Medchemexpress LLC DFBTA | 2966044-07-3 | 99.3% | 393.79 | 50 MG
DFBTA is an orally active and potent ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. It shows analgesic efficacy for inflammatory pain. For research use only and not sold to patients.
- Orally active and potent ANO1 inhibitor
- IC50 of 24 nM for ANO1
- Shows analgesic efficacy for inflammatory pain
- Very weak cytotoxicity and cardiotoxicity (HEK293 proliferation IC50 > 30 μM, hERG IC50 > 30 μM)
- Weak acute toxicity in mice (MLD > 1000 mg/kg)
- Excellent pharmacokinetics properties with oral bioavailability > 75%
- Little brain penetration (<1.5% brain/plasma)
Medchemexpress LLC HY-116807 25mg , Dihydrolipoic Acid CAS:462-20-4 Purity:>98%
HY-116807 25mg Dihydrolipoic Acid CAS: 462-20-4 Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC ABBV-318 | 1802848-94-7 | 98.7% | 405.35 | 1 ML
ABBV-318 is a potent Nav1.7/Nav1.8 blocker, primarily used in research related to pain. It is characterized by high purity and specific activity against human Nav1.7 and Nav1.8 channels.
- Potent Nav1.7/Nav1.8 blocker
- IC50 for hNav1.7: 2.8 μM
- IC50 for hNav1.8: 3.3 μM
- Molecular weight: 405.35
- Formula: C20H15F4N3O2
- Appearance: White to light yellow solid
- Purity: 98.7%
Cayman Chemical PD 166285, Purity: ≥98%, CAS: 185039-89-8, 10 mg
A tyrosine kinase inhibitor; inhibits Src, FGFR1, EGFR, and PDGFRβ (IC50s = 8.4, 39.3, 87.5, and 98.3 nM, respectively), as well as WEE1 (IC50 = 24 nM); inhibits PDGF- or EGF-induced receptor autophosphorylation in VSMCs and A431 cells, respectively, and bFGF-induced tyrosine phosphorylation in Sf9 cells (IC50s = 6.5, 1,600, and 97.3 nM, respectively); inhibits chemotaxis and growth of, as well as adhesion to vitronectin by, VSMCs (IC50s = 80-120 nM); inhibits radiation-induced cell cycle arrest at the G2/M phase and enhances radiation-induced cell death in HT-29 cells; inhibits angiogenesis and induces tumor regression in a 16c murine mammary carcinoma model when administered in combination with PDT at 1, 5, and 10 mg/kg
Medchemexpress LLC MA-0204 25mg | 2095128-17-7 | 25 MG
MA-0204 is a potent, highly selective, orally available peroxisome proliferator-activated receptor delta (PPARδ) modulator supplied for research use. It is characterized by CAS 2095128-17-7, molecular weight 476.49 g/mol, and chemical formula C25H27F3N2O4. The compound is provided at high purity for in vitro and pharmacology studies; it is not for human or veterinary use.
- Potent, selective modulation of PPARδ.
- High purity suitable for research applications.
- Supplied as a solid small-molecule in multiple laboratory pack sizes.
- Appropriate for in vitro pharmacology, SAR, and preclinical studies.
- Not for clinical, human, or veterinary use.